|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.
|
31208298 |
2020 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.
|
31208298 |
2020 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that Snx10 and PIKfyve are involved in the regulation of endosome/lysosome homeostasis via the synthesis of PI(3,5)P2 and may point to a new strategy to prevent bone loss.
|
31692073 |
2020 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period.
|
31208298 |
2020 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autosomal Recessive Osteopetrosis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
TCIRG1 and SNX10 gene mutations in the patients with autosomal recessive osteopetrosis.
|
30898715 |
2019 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in the mouse colorectum and drives inflammation-associated colorectal cancer by a chaperone-mediated autophagy mechanism.
|
29355659 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
SNX10 expression was linked to T category (<i>P</i> = 0.042, χ<sup>2</sup> = 8.708), N category (<i>P</i> = 0.000, χ<sup>2</sup> = 18.778), TNM stage (<i>P</i> = 0.001, χ<sup>2</sup> = 16.744) as well as tumor differentiation (<i>P</i> = 0.000, χ<sup>2</sup> = 251.930).
|
30487700 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results showed that SNX10 deficiency promoted colorectal tumorigenesis in male FVB mice and CRC cell proliferation and survival.
|
29867114 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in the mouse colorectum and drives inflammation-associated colorectal cancer by a chaperone-mediated autophagy mechanism.
|
29355659 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, we found that SNX10 KO promoted tumorigenesis in the mouse colorectum which could be restored by SNX10 over-expression.
|
29355659 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our results showed that SNX10 deficiency promoted colorectal tumorigenesis in male FVB mice and CRC cell proliferation and survival.
|
29867114 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.
|
29867114 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in the mouse colorectum and drives inflammation-associated colorectal cancer by a chaperone-mediated autophagy mechanism.
|
29355659 |
2018 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with WT littermates, Snx10 KO mice exhibited a significant amelioration in ethanol-induced liver injury and hepatic steatosis.
|
29452206 |
2018 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Snx10 knockout (Snx10 KO) mice and their wild-type (WT) littermates fed either the Lieber-DeCarli liquid alcohol diet or a control liquid diet, and primary cultured WT and Snx10 KO hepatocytes stimulated with ethanol, were used as in vivo and in vitro ALD models, respectively.
|
29452206 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we investigated the role of SNX10 in regulating amino-acid metabolism and mTOR signaling pathway activation, as well as the impact on the tumor progression of mouse CRC.
|
29867114 |
2018 |
|
Gastric Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of SA.
|
30487700 |
2018 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with WT littermates, Snx10 KO mice exhibited a significant amelioration in ethanol-induced liver injury and hepatic steatosis.
|
29452206 |
2018 |
|
Malignant neoplasm of liver
|
0.310 |
Biomarker
|
disease |
CTD_human |
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
|
28108177 |
2017 |
|
Malignant neoplasm of liver
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats.
|
28381192 |
2017 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
|
28108177 |
2017 |
|
Osteopetrosis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts.
|
28592808 |
2017 |